Archive for the ‘Science’ Category

Alphabet Evolution

August 18, 2008

A list of common misconceptions

May 1, 2008

  • Warts on human skin are caused by viruses that are unique to humans (Human papillomavirus), and not by proximity to, or contact with, toads.
  • Koalas are not bears. They are not even placental mammals; they are marsupials. The giant panda, however, is a bear, while the red panda is closely related to raccoons.
  • Some bats use echolocation to navigate whilst flying in darkness. Bats are not blind, however. Their eyes are small and poorly developed, but they are still capable of sight, particularly long-range; and in fact can be severely disoriented by excessive light.
  • The claim that a duck’s quack doesn’t echo is false.
  • Jellyfish and starfish are not fish. They are Cnidarians and Echinoderms respectively. Many scientists refer to them as “sea jellies” and “sea stars”.
  • Polar bears do not eat penguins. Polar bears only live in the Arctic, while penguins are not native to the northern hemisphere.
  • The notion that goldfish have a memory of only three seconds is completely false. They have been trained to navigate mazes and can recognise their owners after an exposure of a few months.
  • Lemmings do not engage in suicidal dives off cliffs when migrating. This misconception is due largely to the Disney film White Wilderness, which shot many of the “migration” scenes on a large turntable in a studio. Photographers later pushed the lemmings off a cliff using a broom.
  • Mammal blood is bright red or scarlet when oxygenated and a darker red when not oxygenated. It is never blue. Veins appear blue through the skin because of Rayleigh scattering, the same effect responsible for the blue sky.

How long does it take for a litre of water to go through our body?

April 27, 2008

The short answer is that for normal people it should take about 2 to 3 hours. There is an easy way to find out. Drink a litre of water, and see how long it takes for your rate of urine production to go up and then go back down.

But it depends on several things.

First, the water has to be absorbed. For example, if someone has really bad diarrhea or is vomiting, the fluid won’t be absorbed.

Second, it depends on what is in the water. If it is pure water rather than water with salt in it, the pure water will be excreted faster than salt water.

Third, if someone is dehydrated, say, was playing soccer for two hours and sweated out two more litres water than he drank, the fluid would stay in his body and his rate of urine production will stay really low until he drinks more. And if one lost two litres of water and drinks three litres of water, it will take longer for the rate urine production to increase than if he is not dehydrated.

Forth, it depends on the time of day. Usually, people’s rate of urine production (assuming identical rate of intake of fluid, like if one has an IV) in the middle of the night and increases around the time he wakes up.

Finally, it depends on the state of health of the person. IF a person has kidney disease, the urine production might not increase as much. ANd if a person has heart disease, the fluid may build up in his tissues instead of being excreted.

The reference is a paper where students drank water in the morning and determined how long it took for the water to be excreted. In this paper, it looks like they urinated out about 400 or 500 ml of water over about 2 hours, before the rate of urine production slowed down.

…and how Water Becomes Urine

The water runs down the throat, past the epiglottis (which is closed so that water doesn’t end up in the lungs) and down through the oesophagus into the stomach.

In the stomach, water is needed to assist in the processing and digestion of food. So far, the body has not absorbed any water. The only thing that has happened is that any thirst was probably quenched and the amount of saliva has increased.

The water and food are mixed into a dough and kneaded out into the intestines.

In the small intestine, the body starts to absorb fluid, as well as vitamins and other nutrients from the dough. These nutrients are absorbed by the blood and transported to all the body’s cells…

The large intestine’s task is to absorb as much liquid as possible from the thin batter, so that the body can make use of this liquid and achieve a proper balance of body fluids. This is important, as 60% of the human body is made of water.

The liquid is absorbed by the blood vessels in the large intestine and transported by the blood to the kidneys. In the kidneys, blood is purified and water is converted into urine which flows through the ureters to the bladder. When the bladder contains about 200 – 400ml of urine, signals are usually sent to the brain to promote urination.

10 Important Differences Between Brains and Computers

April 18, 2008

Although the brain-computer metaphor has served cognitive psychology well, research in cognitive neuroscience has revealed many important differences between brains and computers. Appreciating these differences may be crucial to understanding the mechanisms of neural information processing, and ultimately for the creation of artificial intelligence. Below, I review the most important of these differences (and the consequences to cognitive psychology of failing to recognize them): similar ground is covered in this excellent (though lengthy) lecture.

Difference # 1: Brains are analogue; computers are digital

It’s easy to think that neurons are essentially binary, given that they fire an action potential if they reach a certain threshold, and otherwise do not fire. This superficial similarity to digital “1’s and 0’s” belies a wide variety of continuous and non-linear processes that directly influence neuronal processing.

For example, one of the primary mechanisms of information transmission appears to be the rate at which neurons fire – an essentially continuous variable. Similarly, networks of neurons can fire in relative synchrony or in relative disarray; this coherence affects the strength of the signals received by downstream neurons. Finally, inside each and every neuron is a leaky integrator circuit, composed of a variety of ion channels and continuously fluctuating membrane potentials.

Failure to recognize these important subtleties may have contributed to Minksy & Papert’s infamous mischaracterization of perceptrons, a neural network without an intermediate layer between input and output. In linear networks, any function computed by a 3-layer network can also be computed by a suitably rearranged 2-layer network. In other words, combinations of multiple linear functions can be modeled precisely by just a single linear function. Since their simple 2-layer networks could not solve many important problems, Minksy & Papert reasoned that that larger networks also could not. In contrast, the computations performed by more realistic (i.e., nonlinear) networks are highly dependent on the number of layers – thus, “perceptrons” grossly underestimate the computational power of neural networks.

Difference # 2: The brain uses content-addressable memory

In computers, information in memory is accessed by polling its precise memory address. This is known as byte-addressable memory. In contrast, the brain uses content-addressable memory, such that information can be accessed in memory through “spreading activation” from closely related concepts. For example, thinking of the word “fox” may automatically spread activation to memories related to other clever animals, fox-hunting horseback riders, or attractive members of the opposite sex.

The end result is that your brain has a kind of “built-in Google,” in which just a few cues (key words) are enough to cause a full memory to be retrieved. Of course, similar things can be done in computers, mostly by building massive indices of stored data, which then also need to be stored and searched through for the relevant information (incidentally, this is pretty much what Google does, with a few twists).

Although this may seem like a rather minor difference between computers and brains, it has profound effects on neural computation. For example, a lasting debate in cognitive psychology concerned whether information is lost from memory because of simply decay or because of interference from other information. In retrospect, this debate is partially based on the false asssumption that these two possibilities are dissociable, as they can be in computers. Many are now realizing that this debate represents a false dichotomy.

Difference # 3: The brain is a massively parallel machine; computers are modular and serial

An unfortunate legacy of the brain-computer metaphor is the tendency for cognitive psychologists to seek out modularity in the brain. For example, the idea that computers require memory has lead some to seek for the “memory area,” when in fact these distinctions are far more messy. One consequence of this over-simplification is that we are only now learning that “memory” regions (such as the hippocampus) are also important for imagination, the representation of novel goals, spatial navigation, and other diverse functions.

Similarly, one could imagine there being a “language module” in the brain, as there might be in computers with natural language processing programs. Cognitive psychologists even claimed to have found this module, based on patients with damage to a region of the brain known as Broca’s area. More recent evidence has shown that language too is computed by widely distributed and domain-general neural circuits, and Broca’s area may also be involved in other computations (see here for more on this).

Difference # 4: Processing speed is not fixed in the brain; there is no system clock

The speed of neural information processing is subject to a variety of constraints, including the time for electrochemical signals to traverse axons and dendrites, axonal myelination, the diffusion time of neurotransmitters across the synaptic cleft, differences in synaptic efficacy, the coherence of neural firing, the current availability of neurotransmitters, and the prior history of neuronal firing. Although there are individual differences in something psychometricians call “processing speed,” this does not reflect a monolithic or unitary construct, and certainly nothing as concrete as the speed of a microprocessor. Instead, psychometric “processing speed” probably indexes a heterogenous combination of all the speed constraints mentioned above.

Similarly, there does not appear to be any central clock in the brain, and there is debate as to how clock-like the brain’s time-keeping devices actually are. To use just one example, the cerebellum is often thought to calculate information involving precise timing, as required for delicate motor movements; however, recent evidence suggests that time-keeping in the brain bears more similarity to ripples on a pond than to a standard digital clock.

Difference # 5 – Short-term memory is not like RAM

Although the apparent similarities between RAM and short-term or “working” memory emboldened many early cognitive psychologists, a closer examination reveals strikingly important differences. Although RAM and short-term memory both seem to require power (sustained neuronal firing in the case of short-term memory, and electricity in the case of RAM), short-term memory seems to hold only “pointers” to long term memory whereas RAM holds data that is isomorphic to that being held on the hard disk. (See here for more about “attentional pointers” in short term memory).

Unlike RAM, the capacity limit of short-term memory is not fixed; the capacity of short-term memory seems to fluctuate with differences in “processing speed” (see Difference #4) as well as with expertise and familiarity.

Difference # 6: No hardware/software distinction can be made with respect to the brain or mind

For years it was tempting to imagine that the brain was the hardware on which a “mind program” or “mind software” is executing. This gave rise to a variety of abstract program-like models of cognition, in which the details of how the brain actually executed those programs was considered irrelevant, in the same way that a Java program can accomplish the same function as a C++ program.

Unfortunately, this appealing hardware/software distinction obscures an important fact: the mind emerges directly from the brain, and changes in the mind are always accompanied by changes in the brain. Any abstract information processing account of cognition will always need to specify how neuronal architecture can implement those processes – otherwise, cognitive modeling is grossly underconstrained. Some blame this misunderstanding for the infamous failure of “symbolic AI.”

Difference # 7: Synapses are far more complex than electrical logic gates

Another pernicious feature of the brain-computer metaphor is that it seems to suggest that brains might also operate on the basis of electrical signals (action potentials) traveling along individual logical gates. Unfortunately, this is only half true. The signals which are propagated along axons are actually electrochemical in nature, meaning that they travel much more slowly than electrical signals in a computer, and that they can be modulated in myriad ways. For example, signal transmission is dependent not only on the putative “logical gates” of synaptic architecture but also by the presence of a variety of chemicals in the synaptic cleft, the relative distance between synapse and dendrites, and many other factors. This adds to the complexity of the processing taking place at each synapse – and it is therefore profoundly wrong to think that neurons function merely as transistors.

Difference #8: Unlike computers, processing and memory are performed by the same components in the brain

Computers process information from memory using CPUs, and then write the results of that processing back to memory. No such distinction exists in the brain. As neurons process information they are also modifying their synapses – which are themselves the substrate of memory. As a result, retrieval from memory always slightly alters those memories (usually making them stronger, but sometimes making them less accurate – see here for more on this).

Difference # 9: The brain is a self-organizing system

This point follows naturally from the previous point – experience profoundly and directly shapes the nature of neural information processing in a way that simply does not happen in traditional microprocessors. For example, the brain is a self-repairing circuit – something known as “trauma-induced plasticity” kicks in after injury. This can lead to a variety of interesting changes, including some that seem to unlock unused potential in the brain (known as acquired savantism), and others that can result in profound cognitive dysfunction (as is unfortunately far more typical in traumatic brain injury and developmental disorders).

One consequence of failing to recognize this difference has been in the field of neuropsychology, where the cognitive performance of brain-damaged patients is examined to determine the computational function of the damaged region. Unfortunately, because of the poorly-understood nature of trauma-induced plasticity, the logic cannot be so straightforward. Similar problems underlie work on developmental disorders and the emerging field of “cognitive genetics”, in which the consequences of neural self-organization are frequently neglected .

Difference # 10: Brains have bodies

This is not as trivial as it might seem: it turns out that the brain takes surprising advantage of the fact that it has a body at its disposal. For example, despite your intuitive feeling that you could close your eyes and know the locations of objects around you, a series of experiments in the field of change blindness has shown that our visual memories are actually quite sparse. In this case, the brain is “offloading” its memory requirements to the environment in which it exists: why bother remembering the location of objects when a quick glance will suffice? A surprising set of experiments by Jeremy Wolfe has shown that even after being asked hundreds of times which simple geometrical shapes are displayed on a computer screen, human subjects continue to answer those questions by gaze rather than rote memory. A wide variety of evidence from other domains suggests that we are only beginning to understand the importance of embodiment in information processing.

Bonus Difference: The brain is much, much bigger than any [current] computer

Accurate biological models of the brain would have to include some 225,000,000,000,000,000 (225 million billion) interactions between cell types, neurotransmitters, neuromodulators, axonal branches and dendritic spines, and that doesn’t include the influences of dendritic geometry, or the approximately 1 trillion glial cells which may or may not be important for neural information processing. Because the brain is nonlinear, and because it is so much larger than all current computers, it seems likely that it functions in a completely different fashion. (See here for more on this.) The brain-computer metaphor obscures this important, though perhaps obvious, difference in raw computational power.